135859-72-2Relevant academic research and scientific papers
Enzymatic kinetic resolution of tropic acid
Klomp, Dirk,Peters, Joop A.,Hanefeld, Ulf
, p. 3892 - 3896 (2005)
A new strategy has been developed for the CAL-B catalysed kinetic resolution of tropic acid by which both enantiomers of tropic acid can be obtained in good enantiomeric excess. (R)-Tropic acid was synthesised with 90% ee and (S)-tropic acid butyl ester in 99% ee by the hydrolysis of tropic acid butyl ester. The other enantiomers were available through the enzymatically catalysed reaction of tropic acid lactone with butanol to give (S)-tropic acid lactone and (R)-tropic acid ester in >98% ee.
