13586-83-9

Upstream product

• 140-10-3 (E)-3-phenylacrylic acid 
• 7664-93-9 sulfuric acid 
• 7446-11-9 sulfur trioxide 
• 621-82-9 Cinnamic acid 

Downstream Products

• 140-10-3 (E)-3-phenylacrylic acid 
• 636-78-2 4-sulphobenzoic acid 
• 621-82-9 Cinnamic acid 
• 501-52-0 3-Phenylpropionic acid 
• 99-96-7 4-hydroxy-benzoic acid 

Relevant academic research and scientific papers

Iron(ii) coordination pyrazole complexes with aromatic sulfonate ligands: The role of ether

Four novel heteroleptic mononuclear Fe(ii) coordination complexes including 3,5-dimethyl-1-(2′-pyridyl)-pyrazole (DMPP) and aromatic sulfonate ligands were synthesized and characterized using single crystal-XRD, SQUID magnetometry and 57Fe M?ssbauer spectroscopy. The crystal structures of the complexes revealed the unusual coordination of sulfonate groups to Fe(ii) ions, leading to an Fe-N4O2 coordination environment. This specific molecular layout is presumably caused by diethyl ether, which was vapour diffused into the complexation medium to obtain crystalline complexes. Alongside yielding single crystals, diethyl ether also altered the self-assembly process of a usual FeN6 homoleptic coordination environment. All the complexes remain paramagnetic at all temperatures as suggested by magnetic susceptibility measurements. All are stable in air except [Fe(DMPP)2(tos)2] which got partially oxidized to Fe(iii) over time as suggested by 57Fe M?ssbauer spectroscopy. This journal is

8-(Sulfostyryl)xanthines: Water-soluble A(2A)-selective adenosine receptor antagonists

8-(Sulfostyryl)xanthine derivatives were synthesized as water-soluble A(2A)-selective adenosine receptor (AR) antagonists. meta- and para-sulfostyryl-DMPX (3,7-dimethyl-1-propargylxanthine) derivatives 11a and 11b exhibited high affinity to rat A(2A)-AR in submicromolar concentrations, and were 20- to 30-fold selective versus rat A1-AR. Styryl-DMPX derivatives were inactive at human A(2B)- and A3-AR. 1,3-Dipropyl-8-p-sulfostyrylxanthine (13) and its 7-methyl derivative (14) showed similar (13) or higher (14) A(2A) affinity than 11a and 11b but showed no (13) or only a low degree (14) of selectivity versus A1-, A(2B)-, and A3-AR. The A(2A)-selective sulfostyryl-DMPX derivatives exhibit high water-solubility and may be useful research tools for in vivo studies. Copyright (C) 1998 Elsevier Science Ltd.