1358684-71-5

Basic information

• Product Name: tert-butyl (2-bromo-5-fluorobenzyl)carbamate
• Synonyms: tert-butyl (2-bromo-5-fluorobenzyl)carbamate
• CAS NO: 1358684-71-5
• Molecular Weight: 304.159
• Mol File: 1358684-71-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl (2-bromo-5-fluorobenzyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2-bromo-5-fluorobenzyl)carbamate(1358684-71-5)
• EPA Substance Registry System: tert-butyl (2-bromo-5-fluorobenzyl)carbamate(1358684-71-5)

Safety Data

• Hazardous Substances Data: 1358684-71-5(Hazardous Substances Data)

Usage

General Description

Tert-butyl (2-bromo-5-fluorobenzyl)carbamate is a chemical compound that belongs to the class of carbamate derivatives. It is commonly used as a reagent in organic synthesis and pharmaceutical research. tert-butyl (2-bromo-5-fluorobenzyl)carbamate is characterized by the presence of a tert-butyl group and a carbamate functional group, which makes it a versatile building block for the synthesis of various pharmaceutical compounds. The presence of the bromine and fluorine substituents in the benzyl group also imparts specific properties to the compound, allowing for selective reactions in synthetic processes. Tert-butyl (2-bromo-5-fluorobenzyl)carbamate is widely used in the pharmaceutical industry for the development of new drugs and has a range of potential applications in medicinal chemistry and drug discovery.

Upstream product

• 747392-34-3 1-(2-bromo-5-fluorophenyl)methanamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 202865-62-1 C₇H₅BrFNO 
• 94569-84-3 2-bromo-5-fluorobenzaldehyde 
• 202865-67-6 (2-bromo-5-fluorophenyl)methanamine hydrochloride 

Downstream Products

• 1410130-90-3 3-cyclohexyl-8-fluoro-6,10b-dihydro-1H-[1,2,4]thiadiazino[5,4-a]isoindol-4(3H)-one 2,2-dioxide 
• 1410130-92-5 3-(4-chlorobenzyl)-8-fluoro-6,10b-dihydro-1H-[1,2,4]thiadiazino[5,4-a]isoindol-4(3H)-one 2,2-dioxide 
• 1410130-97-0 8-fluoro-3-(1-phenylethyl)-6,10b-dihydro-1H-[1,2,4]thiadiazino[5,4-a]isoindol-4(3H)-one 2,2-dioxide 
• 1410130-81-2 3-(3,4-dimethoxyphenylethyl)-8-fluoro-3,4,6,10b-tetrahydro-1H-[1,2,4]thiadiazino[5,4-a]isoindole 2,2-dioxide 
• 1410130-88-9 3-(cyclohexylmethyl)-8-fluoro-3,4,6,10b-tetrahydro-1H-[1,2,4]thiadiazino[5,4-a]isoindole 2,2-dioxide 
• 1410130-96-9 3-(4-chlorobenzyl)-8-fluoro-3,4,6,10b-tetrahydro-1H-[1,2,4]thiadiazino[5,4-a]isoindole 2,2-dioxide 
• 1410131-00-8 8-fluoro-3-(1-phenylethyl)-3,4,6,10b-tetrahydro-1H-[1,2,4]thiadiazino[5,4-a]isoindole 2,2-dioxide 
• 1410130-78-7 3-(3,4-dimethoxyphenylethyl)-8-fluoro-6,10b-dihydro-1H-[1,2,4]thiadiazino[5,4-a]isoindol-4(3H)-one 2,2-dioxide 
• 1410130-85-6 3-(cyclohexylmethyl)-8-fluoro-6,10b-dihydro-1H-[1,2,4]thiadiazino[5,4-a]isoindol-4(3H)-one 2,2-dioxide 
• 1410130-14-1 C₂₀H₂₉FN₂O₄S 
• 1410130-10-7 C₂₁H₂₄ClFN₂O₄S 
• 1410130-16-3 C₂₁H₃₁FN₂O₄S 
• 1410130-19-6 C₂₄H₃₉FN₂O₄S 
• 1410130-21-0 C₂₄H₃₁FN₂O₆S 

Relevant articles and documents

Asymmetric Hydrogenation of Dibenzo[ c,e]azepine Derivatives with Chiral Cationic Ruthenium Diamine Catalysts

An efficient Ru-catalyzed asymmetric hydrogenation of dibenzo[c,e]azepines is reported. A series of seven-membered cyclic amines were obtained with moderate to excellent enantioselectivity. The catalyst counteranion played an important role in achieving high-level chiral induction. Moreover, a one-pot synthesis of chiral 6,7-dihydro-5H-dibenz[c,e]azepines via two-step reductive amination was also developed.

Palladium-Catalyzed α-Arylation of Silylenol Ethers in the Synthesis of Isoquinolines and Phenanthridines

A diverse array of isoquinolines and phenanthridines have been accessed by developing a two-step, one-pot method constituting regioselective palladium-catalyzed Kuwajima-Urabe α-arylation of silylenol ethers and acid-mediated deprotection, annulation, and aromatization. Structural diversity in the silylenol ethers leads to three different classes of isoquinolines and phenanthridines from which related natural products can be derived. The synthetic utility of this method by the quick assembly of the natural product trispheridine is also demonstrated.