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Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl (2-bromo-5-fluorobenzyl)carbamate is used as a key intermediate in the synthesis of new drugs for various therapeutic applications. Its unique structural features allow for the development of innovative drug candidates with improved pharmacological properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, tert-butyl (2-bromo-5-fluorobenzyl)carbamate is employed as a versatile building block for the design and synthesis of bioactive molecules. Its presence in the molecular structure can modulate the physicochemical and pharmacokinetic properties of the resulting compounds, enhancing their therapeutic potential.
Used in Drug Discovery:
Tert-butyl (2-bromo-5-fluorobenzyl)carbamate plays a crucial role in drug discovery, where it is utilized to explore novel chemical space and identify potential drug candidates. Its unique structural features and reactivity enable the generation of diverse chemical libraries, facilitating the identification of promising lead compounds for further optimization and development.

Upstream product

• 747392-34-3 1-(2-bromo-5-fluorophenyl)methanamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 202865-62-1 C₇H₅BrFNO 
• 94569-84-3 2-bromo-5-fluorobenzaldehyde 
• 202865-67-6 (2-bromo-5-fluorophenyl)methanamine hydrochloride 

Downstream Products

• 1358685-27-4 C₂₁H₂₅FN₂O₄S 
• 1358685-21-8 C₁₉H₂₇FN₂O₄S 
• 1358685-28-5 C₂₂H₂₇FN₂O₅S 
• 1358685-23-0 C₂₂H₃₅FN₂O₄S 
• 1135318-19-2 7-fluoro-3-phenylisoquinoline 

Relevant academic research and scientific papers

Asymmetric Hydrogenation of Dibenzo[ c,e]azepine Derivatives with Chiral Cationic Ruthenium Diamine Catalysts

An efficient Ru-catalyzed asymmetric hydrogenation of dibenzo[c,e]azepines is reported. A series of seven-membered cyclic amines were obtained with moderate to excellent enantioselectivity. The catalyst counteranion played an important role in achieving high-level chiral induction. Moreover, a one-pot synthesis of chiral 6,7-dihydro-5H-dibenz[c,e]azepines via two-step reductive amination was also developed.

COMPOSITIONS AND USES THEREOF

The present invention relates to compositions and methods for the treatment of disorders that lead to accumulation of oxalate, such as primary hyperoxaluria 1.

Palladium-Catalyzed α-Arylation of Silylenol Ethers in the Synthesis of Isoquinolines and Phenanthridines

A diverse array of isoquinolines and phenanthridines have been accessed by developing a two-step, one-pot method constituting regioselective palladium-catalyzed Kuwajima-Urabe α-arylation of silylenol ethers and acid-mediated deprotection, annulation, and aromatization. Structural diversity in the silylenol ethers leads to three different classes of isoquinolines and phenanthridines from which related natural products can be derived. The synthetic utility of this method by the quick assembly of the natural product trispheridine is also demonstrated.