1358685-06-9Relevant academic research and scientific papers
Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy
Zang, Qin,Javed, Salim,Porubsky, Patrick,Ullah, Farman,Neuenswander, Benjamin,Lushington, Gerald H.,Basha, Fatima Z.,Organ, Michael G.,Hanson, Paul R.
, p. 211 - 217 (2012/05/19)
The synthesis of a unique isoindoline- and tetrahydroisoquinoline (THIQ)-containing tricyclic sultam library, utilizing a Heck-aza-Michael (HaM) strategy is reported. Both isoindoline and THIQ rings are installed through a Heck reaction on a vinylsulfonamide, followed by one-pot deprotection and intramolecular aza-Michael reaction. Subsequent cyclization with either paraformaldehyde condensation or 1,1′-carbonyldiimidazole coupling generates a variety of tricyclic sultams. Overall, a 160-member library of these sultams, together with their isoindolines/THIQ and secondary sulfonamides precursors, were constructed using this strategy.
