135875-40-0

Upstream product

• 106-95-6 allyl bromide 
• 40691-13-2 3-(carboxymethyl)-4,5-diphenyl-1-oxazolin-2-one 

Downstream Products

• 135875-41-1 (2S,3S)-3-Hydroxy-4-methyl-2-(2-oxo-4,5-diphenyl-oxazol-3-yl)-pent-4-enoic acid allyl ester 
• 135875-44-4 (S)-[(2R,3R)-3-Hydroxy-4-methyl-2-(2-oxo-4,5-diphenyl-oxazol-3-yl)-pent-4-enoylamino]-(4-methoxy-phenyl)-acetic acid methyl ester 
• 135875-46-6 (S)-[(2R,3S)-2-Isopropenyl-4-oxo-3-(2-oxo-4,5-diphenyl-oxazol-3-yl)-azetidin-1-yl]-(4-methoxy-phenyl)-acetic acid methyl ester 
• 135875-43-3 (S)-[(2R,3R)-3-Hydroxy-4-methyl-2-(2-oxo-4,5-diphenyl-oxazol-3-yl)-pent-4-enoylamino]-phenyl-acetic acid methyl ester 
• 135875-45-5 (S)-[(2R,3S)-2-Isopropenyl-4-oxo-3-(2-oxo-4,5-diphenyl-oxazol-3-yl)-azetidin-1-yl]-phenyl-acetic acid methyl ester 
• 135875-48-8 (R)-((2S,3S)-2-Acetyl-3-benzoylamino-4-oxo-azetidin-1-yl)-(4-methoxy-phenyl)-acetic acid methyl ester 
• 135875-50-2 (R)-[3-Benzoylamino-2-(1-hydroxy-ethyl)-4-oxo-azetidin-1-yl]-(4-methoxy-phenyl)-acetic acid methyl ester 
• 135875-52-4 (S)-((3R,4R)-4-Benzoylamino-2-methyl-5-oxo-tetrahydro-furan-3-ylamino)-(4-methoxy-phenyl)-acetic acid methyl ester 
• 135875-42-2 (2S,3S)-3-Hydroxy-4-methyl-2-(2-oxo-4,5-diphenyl-oxazol-3-yl)-pent-4-enoic acid 
• 135875-47-7 (R)-((2S,3S)-2-Acetyl-3-benzoylamino-4-oxo-azetidin-1-yl)-phenyl-acetic acid methyl ester 
• 135875-49-9 (R)-[3-Benzoylamino-2-(1-hydroxy-ethyl)-4-oxo-azetidin-1-yl]-phenyl-acetic acid methyl ester 
• 135875-51-3 (R)-((3S,4S)-4-Benzoylamino-2-methyl-5-oxo-tetrahydro-furan-3-ylamino)-phenyl-acetic acid methyl ester 

Relevant academic research and scientific papers

Diastereoselective Synthesis of the Carbacephem Framework

A short, versatile, and diastereoselective method of preparing carbacephems has been developed.The procedure involves as a key step the aldol condensation of a protected glycine compound with a suitably designed aldehyde.In this step, most of the carbon skeleton of the carbacephem is assembled, and the two stereocenters of the final β-lactam are set.This step also provides well-placed and synthetically useful functionality for further elaboration into the desired target.