13590-98-2

Usage

Uses

Used in Pharmaceutical Industry:
Proguanil Related Compound C (25 mg) (1,5-bis(4-chlorophenyl)biguanide hydrochloride) is used as an impurity reference for the synthesis of Chlorguanide (C329500), an antimalarial drug. Its presence is crucial for quality control and assurance during the drug manufacturing process, ensuring the purity and safety of the final product.
Used in Research and Development:
In the field of research and development, Proguanil Related Compound C (25 mg) (1,5-bis(4-chlorophenyl)biguanide hydrochloride) serves as a valuable compound for studying the synthesis, properties, and potential applications of related biguanide derivatives. This can lead to the discovery of new antimalarial drugs or other therapeutic agents with similar mechanisms of action.
Used in Quality Control and Analytical Chemistry:
Proguanil Related Compound C (25 mg) (1,5-bis(4-chlorophenyl)biguanide hydrochloride) is utilized as a reference material in the development and validation of analytical methods for the detection and quantification of impurities in antimalarial drugs. This helps to maintain the quality and efficacy of these medications, ultimately benefiting patients who rely on them for treatment.

Downstream Products

• 858-07-1 N,N'-bis-(4-chloro-phenyl)-6-trifluoromethyl-[1,3,5]triazine-2,4-diamine 

Relevant academic research and scientific papers

Biguanide Derivative, A Preparation Method Thereof And A Pharmaceutical Composition Containing The Biguanide Derivative As An Active Ingredient

A biguanide derivative compound with N1-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPKα and inhibition of cancer cell proliferation in a low dose, compared to conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.

BIGUANIDE DERIVATIVE, A PREPARATION METHOD THEREOF AND A PHARMACEUTICAL COMPOSITION CONTAINING THE BIGUANIDE DERIVATIVE AS AN ACTIVE INGREDIENT

A biguanide derivative compound with N1-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPKα and inhibition of cancer cell proliferation in a low dose, compared to conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.