1359058-07-3Relevant academic research and scientific papers
Effective synthesis of 1,5-disubstituted 2,1-benzisothiazol-3(1H)-ones
Kharul, Rajendra K.,Prajapati, Pinkal N.,Thorave, Amol A.,Shah, Hardik A.,Dhar, Arghya,Joshi, Darshan A.,Jain, Mukul R.,Patel, Pankaj R.,Pancholi
, p. 3265 - 3279 (2011/09/16)
A convenient and effective synthesis of novel 1,5-disubstituted 2,1-benzisothiazol-3(1H)-one derivatives is described. The approach involves nitration of inexpensive isatoic anhydride followed by its conversion to 5-nitro-2,1-benzisothiazol-3(1H)-ones in excellent yield and alkylation at the 1-position. The 5-amino group was further derivatized.
