135911-83-0

Basic information

• Product Name: {(1S,2S,4R)-1-Benzyl-4-[((S)-carbamoyl-phenyl-methyl)-carbamoyl]-2-hydroxy-5-phenyl-pentyl}-carbamic acid tert-butyl ester
• CAS NO: 135911-83-0
• Molecular Weight: 545.679
• Mol File: 135911-83-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {(1S,2S,4R)-1-Benzyl-4-[((S)-carbamoyl-phenyl-methyl)-carbamoyl]-2-hydroxy-5-phenyl-pentyl}-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {(1S,2S,4R)-1-Benzyl-4-[((S)-carbamoyl-phenyl-methyl)-carbamoyl]-2-hydroxy-5-phenyl-pentyl}-carbamic acid tert-butyl ester(135911-83-0)
• EPA Substance Registry System: {(1S,2S,4R)-1-Benzyl-4-[((S)-carbamoyl-phenyl-methyl)-carbamoyl]-2-hydroxy-5-phenyl-pentyl}-carbamic acid tert-butyl ester(135911-83-0)

Safety Data

• Hazardous Substances Data: 135911-83-0(Hazardous Substances Data)

Upstream product

• 60079-51-8 (S)-phenylglycinamide hydrochloride 
• 98818-51-0 N-(1,1-dimethylethoxycarbonyl)-5(S)-amino-4(S)-(t-butyldimethylsilyloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoic acid 

Relevant articles and documents

Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679

A series of tetrapeptide analogues of 1 (L-682,679), in which the carboxy terminus has been shortened and modified, was prepared and their inhibitory activity measured against the HIV protease in a peptide cleavage assay. Selected examples were tested as inhibitors of virus spread in cell culture. Compound 12 was a 10-fold more potent enzyme inhibitor than 1 in vitro and 30-fold more potent in inhibiting the viral spread in cells.