135925-13-2Relevant academic research and scientific papers
KF/Al2O3: Solid-supported reagent used in 1,3-dipolar cycloaddition reaction of nitrile oxide
Boruah, Monalisa,Konwar, Dilip
experimental part, p. 3261 - 3268 (2012/09/11)
The stereoselective synthesis of 2-isoxazolidine through 1,3-dipolar cycloaddition reaction of nitrile oxide, which is in situ generation from aldoxime in the presence of N-bromosuccinamide and solid-supported reagent KF/Al2O3 at room temperature, is reported. KF/Al2O3 is sufficiently basic such that it can replace organic bases such as Et 3N used in typical procedures and it catalyses the reaction to enhance the rate of the reaction.
