135950-48-0Relevant academic research and scientific papers
Palladium on carbon: An efficient, heterogeneous and reusable catalytic system for carbonylative synthesis of N-substituted phthalimides
Khedkar, Mayur V.,Khan, Shoeb R.,Sawant, Dinesh N.,Bagal, Dattatraya B.,Bhanage, Bhalchandra M.
, p. 3415 - 3422 (2011)
The application of palladium on carbon (Pd/C) as a heterogeneous recyclable catalyst was investigated for the double carbonylation of o-dihaloarenes with amines providing excellent yield of N-substituted phthalimides in shorter reaction time as compared to earlier reported homogeneous protocols. Furthermore, the scope of the developed protocol was applied for the synthesis N-substituted phthalimides from o-halobenzoates and o-halobenzoic acid via a single step carbonylative cyclization reaction. The developed methodology describes an efficient one-step approach for the synthesis of an important class of heterocycles and tolerates a wide variety of functional groups. It circumvents the use of phosphine ligands with an additional advantage of catalyst recyclability for up to eight consecutive cycles. Copyright
Ruthenium(II)-catalyzed N-substituted phthalimide synthesis via C-H activation/[3+2] annulation
Dong, Xue-Fen,Fan, Juan,Shi, Xian-Ying,Liu, Ke-Yan,Wang, Peng-Min,Wei, Jun-Fa
, p. 55 - 61 (2015/02/18)
Ruthenium-catalyzed intermolecular [3 + 2] annulation pathway for aromatic acids with isocyanates to afford N-substituted phthalimide in one step is demonstrated, which provides an efficient process to direct preparation of phthalimide from commercially a
