1359754-84-9Relevant academic research and scientific papers
Discovery and structural insight of a highly selective protein kinase inhibitor hit through click chemistry
Gu, Guoxian,Wang, Huihui,Liu, Pi,Fu, Chenzeng,Li, Zhonghua,Cao, Xuefeng,Li, Yunping,Fang, Qinghong,Xu, Feng,Shen, Jie,Wang, Peng George
, p. 2788 - 2790 (2012/04/23)
Novel bisaryl maleimide derivatives to mimic natural kinase inhibitors were prepared through click chemistry. A highly selective hit was discovered in a 124-kinase-assay, and docking studies revealed a π-π stacking interaction with the Phe67 at the P-loop of GSK-3β kinase. The Royal Society of Chemistry 2012.
