1359868-31-7

Basic information

• Product Name: (E)-Ethyl 3-(4-Morpholinophenyl)Acrylate
• Synonyms: (E)-Ethyl 3-(4-Morpholinophenyl)Acrylate;(E)-Ethyl 3-(4-Morpholinophenyl)Acrylate(WXC03617)
• CAS NO: 1359868-31-7
• Molecular Formula: C15H19NO3
• Molecular Weight: 261.31626
• Mol File: 1359868-31-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 428.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.135±0.06 g/cm3(Predicted)
• PKA: 3.10±0.40(Predicted)
• CAS DataBase Reference: (E)-Ethyl 3-(4-Morpholinophenyl)Acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-Ethyl 3-(4-Morpholinophenyl)Acrylate(1359868-31-7)
• EPA Substance Registry System: (E)-Ethyl 3-(4-Morpholinophenyl)Acrylate(1359868-31-7)

Safety Data

• Hazardous Substances Data: 1359868-31-7(Hazardous Substances Data)

Usage

General Description

(E)-Ethyl 3-(4-Morpholinophenyl)Acrylate, also known as Acrisorcin, is a chemical compound with the molecular formula C14H17NO3. It is an ester that is commonly used in the synthesis of pharmaceuticals and organic compounds. It has been found to exhibit various biological activities, including anticancer, anti-inflammatory, and antimicrobial properties. (E)-Ethyl 3-(4-Morpholinophenyl)Acrylate is also used in the manufacturing of cosmetics and personal care products due to its ability to act as an emollient and moisturizer. However, it is important to handle this chemical with care as it may cause irritation to the eyes, skin, and respiratory system, and is harmful if swallowed. Overall, (E)-Ethyl 3-(4-Morpholinophenyl)Acrylate has a wide range of applications in the pharmaceutical and cosmetic industries.

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 1204-86-0 4-(4-morpholinyl)benzaldehyde 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 92-53-5 4-Phenylmorpholine 
• 140-88-5 ethyl acrylate 

Relevant articles and documents

Nickel-Catalyzed Reductive Csp2-Csp3Cross Coupling Using Phosphonium Salts

A nickel-catalyzed reductive cross coupling with phosphonium salts and allylic C(sp3)-O bond electrophiles, which granted direct construction of the C(sp2)-C(sp3) bond, is successfully developed. The protocol features broad substrate scope, high-functional-group tolerance, and heterocycle compatibility. Notably, the much more challenging reductive cross coupling with heterocyclic thiazolylphosphonium salts has also been accomplished for the first time.

Para-Selective C-H Olefination of Aniline Derivatives via Pd/S,O-Ligand Catalysis

Herein we report a highly para-selective C-H olefination of aniline derivatives by a Pd/S,O-ligand-based catalyst. The reaction proceeds under mild reaction conditions with high efficiency and broad substrate scope, including mono-, di-, and trisubstituted tertiary, secondary, and primary anilines. The S,O-ligand is responsible for the dramatic improvements in substrate scope and the high para-selectivity observed. This methodology is operationally simple, scalable, and can be performed under aerobic conditions.