13599-78-5

Usage

Family

Benzothiadiazole

Nitro group position

5th

Usage

Building block in the synthesis of various organic materials

Applications

a. Polymers
b. Dyes
c. Organic electronics
d. Optoelectronics
e. Materials science

Unique structure

Contributes to its versatility in material development

Industrial and technological purposes

Development of new and advanced materials

Upstream product

• 7686-29-5 2-amino-4-nitrobenzenethiol 
• 273-77-8 benzo[1,2,3]thiadiazole 
• 137-07-5 2-amino-benzenethiol 
• 7664-93-9 sulfuric acid 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 10403-47-1 2-bromo 5-nitroaniline 

Downstream Products

• 1753-29-3 1,2,3-benzothiadiazol-5-amine 

Relevant academic research and scientific papers

Method for continuously synthesizing benzothiadiazole compound

The invention discloses a method for continuously synthesizing a benzothiadiazole compound, comprising the following step: by using an o-mercaptoaniline compound, sodium nitrite and water as reactionsubstrates in a continuous flow reactor, a diazotization-coupling reaction is carried out at certain temperature under certain pressure to obtain the benzothiadiazole compound. By adopting the technology, no protonic acid participates, and water is used as a reactant and a solvent, so that the method is green and environment-friendly. The continuous flow reactor is used, online materials are small, the process is intrinsically safe, and the method is suitable for large-scale production.

Synthesis method of 1,2,3-diazosulfide compound

The invention discloses a synthesis method of a 1,2,3-diazosulfide compound. A o-aminothiophenol compound with a structure shown as a formula (I) and tert-butyl nitrite are taken as raw materials, and are subjected to intramolecular diazo-reaction to obtain the 1,2,3-diazosulfide compound with a structure shown as a formula (II); a reaction equation is as follows (shown in the description), wherein R=hydrogen, fluorine, chlorine, ester group, nitro or methyl. The synthesis method has the beneficial effects that (1) the operation is simple and convenient in a preparation process, an obtained product is easy for after-treatment, and large-scale industrialized production is suitable; (2) reaction conditions are mild; (3) the synthesis cost is lowered; (4) a reaction substrate is high in functional group tolerance, is wide in range and easy to prepare; (5) the reaction is efficient, the yield is high, and the reaction efficiency is higher after reaction amplification; (6) environment pollution is avoided, and environment friendliness is achieved.

AMINO-QUINOLINES AS KINASE INHIBITORS

Disclosed are quinoline compounds having the formula: wherein R1, R2 and A are as defined herein, and methods of making and using the same.

7-AMINOFUROPYRIDINE DERIVATIVES

Compounds of Formula 1, as shown below and defined herein: pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by TAK1 or for which an appropriate TAK1 inhibitor is effective. This Abstract is not limiting of the invention.