1359964-65-0

Basic information

• Product Name: 2-(2-(2-hydroxy-3-(2-methylallyl)benzylidene)hydrazinyl)-4-phenylpyrido[2,3-b]pyrazin-3(4H)-one
• CAS NO: 1359964-65-0
• Molecular Weight: 411.463
• Mol File: 1359964-65-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-(2-hydroxy-3-(2-methylallyl)benzylidene)hydrazinyl)-4-phenylpyrido[2,3-b]pyrazin-3(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(2-hydroxy-3-(2-methylallyl)benzylidene)hydrazinyl)-4-phenylpyrido[2,3-b]pyrazin-3(4H)-one(1359964-65-0)
• EPA Substance Registry System: 2-(2-(2-hydroxy-3-(2-methylallyl)benzylidene)hydrazinyl)-4-phenylpyrido[2,3-b]pyrazin-3(4H)-one(1359964-65-0)

Safety Data

• Hazardous Substances Data: 1359964-65-0(Hazardous Substances Data)

Upstream product

• 5470-18-8 2-Chloro-3-nitropyridine 
• 1333931-07-9 2-hydrazinyl-4-phenylpyrido[2,3-b]pyrazin-3(4H)-one 
• 162971-77-9 2-(β-methylallyl)phenol-6-carbaldehyde 
• 1334103-16-0 1,4-dihydro-4-phenylpyrido[2,3-b]pyrazine-2,3-dione 
• 1334103-17-1 2-chloro-4-phenylpyrido[2,3-b]pyrazin-3(4H)-one 
• 34949-41-2 3-nitro-2-phenylaminopyridine 
• 62-53-3 aniline 
• 41010-49-5 3-amino-2-phenylaminopyridine 

Relevant articles and documents

Synthesis and cytotoxicity studies of novel 2-hydrazonylpyrido[2,3-b] pyrazin-3(4H)-ones

In an attempt to develop potent antitumor agents, a series of novel 2-hydrazonylpyrido[2,3-b]pyrazin-3(4H)-one derivatives were designed and synthesized. All the prepared compounds were screened for their cytotoxic activities against A549, MDA-MB-231 and HT-29 cell lines in vitro. Pharmacological data indicated that five of the target compounds showed cytotoxicity against A549 cell line below a concentration of 1 μM. Compound 15g was the most potent one with IC50 values of 0.19, 2.11 and 2.15 μM against A549, MDA-MB-231 and HT29 cell lines, respectively. A series of 2-hydrazonylpyrido[2,3-b]pyrazin-3(4H)-one derivatives was designed and synthesized. Preliminary structure-activity relationships suggested that compounds with 4-methoxyphenyl or 4-(trifluoromethoxy)phenyl groups on the N-4 position were generally more potent than those with an unsubstituted phenyl group. Copyright