1359969-45-1

Basic information

• Product Name: methyl (9S,12S,15S)-15-{[(benzyloxy)carbonyl]amino}-12-(2-methylpropyl)-11,14-dioxo-2-oxa-5,6,7,10,13-pentaazatricyclo[15.2.2.1(4,7)]docosa-1⁽¹⁹⁾,4⁽²²⁾,5,17,20-pentaene-9-carboxylate
• Synonyms: methyl (9S,12S,15S)-15-{[(benzyloxy)carbonyl]amino}-12-(2-methylpropyl)-11,14-dioxo-2-oxa-5,6,7,10,13-pentaazatricyclo[15.2.2.1(4,7)]docosa-1⁽¹⁹⁾,4⁽²²⁾,5,17,20-pentaene-9-carboxylate
• CAS NO: 1359969-45-1
• Molecular Weight: 592.652
• Mol File: 1359969-45-1.mol

Chemical Properties

• CAS DataBase Reference: methyl (9S,12S,15S)-15-{[(benzyloxy)carbonyl]amino}-12-(2-methylpropyl)-11,14-dioxo-2-oxa-5,6,7,10,13-pentaazatricyclo[15.2.2.1(4,7)]docosa-1⁽¹⁹⁾,4⁽²²⁾,5,17,20-pentaene-9-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (9S,12S,15S)-15-{[(benzyloxy)carbonyl]amino}-12-(2-methylpropyl)-11,14-dioxo-2-oxa-5,6,7,10,13-pentaazatricyclo[15.2.2.1(4,7)]docosa-1⁽¹⁹⁾,4⁽²²⁾,5,17,20-pentaene-9-carboxylate(1359969-45-1)
• EPA Substance Registry System: methyl (9S,12S,15S)-15-{[(benzyloxy)carbonyl]amino}-12-(2-methylpropyl)-11,14-dioxo-2-oxa-5,6,7,10,13-pentaazatricyclo[15.2.2.1(4,7)]docosa-1⁽¹⁹⁾,4⁽²²⁾,5,17,20-pentaene-9-carboxylate(1359969-45-1)

Safety Data

• Hazardous Substances Data: 1359969-45-1(Hazardous Substances Data)

Upstream product

• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 1359969-39-3 (5S,8S,11S)-methyl 11-(azidomethyl)-8-isobutyl-3,6,9-trioxo-1-phenyl-5-(4-(prop-2-yn-1-yloxy)benzyl)-2-oxa-4,7,10-triazadodecan-12-oate 
• 1359969-36-0 (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoic acid 
• 1359969-32-6 (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate 
• 1359969-23-5 (S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanoic acid 

Downstream Products

• 1359968-93-6 benzyl N-[(9S,12S,15S)-9-formyl-12-(2-methylpropyl)-11,14-dioxo-2-oxa-5,6,7,10,13-pentaazatricyclo[15.2.2.1(4,7)]docosa-1⁽¹⁹⁾,4⁽²²⁾,5,17,20-pentaen-15-yl]carbamate 
• 1359969-51-9 benzyl N-[(9S,12S,15S)-9-(hydroxymethyl)-12-(2-methylpropyl)-11,14-dioxo-2-oxa-5,6,7,10,13-pentaazatricyclo[15.2.2.1(4,7)]docosa-1⁽¹⁹⁾,4⁽²²⁾,5,17,20-pentaen-15-yl]carbamate 

Relevant articles and documents

New β-strand templates constrained by Huisgen cycloaddition

New peptidic templates constrained into a β-strand geometry by linking acetylene and azide containing P1 and P3 residues of a tripeptide by Huisgen cycloaddition are presented. The conformations of the macrocycles are defined by NMR studies and those that best define a β-strand are shown to be potent inhibitors of the protease calpain. The β-strand templates presented and defined here are prepared under optimized conditions that should be suitable for targeting a range of proteases and other applications requiring such a geometry.