1359971-48-4Relevant academic research and scientific papers
Protecting group free, stereocontrolled synthesis of β-halo-enamides
Pasqua, Adele E.,Crawford, James J.,Long, De-Liang,Marquez, Rodolfo
experimental part, p. 2149 - 2158 (2012/05/20)
Enamides, dienamides, and enynamides are important building blocks in synthetic, biological, and medicinal chemistry as well as materials science. Despite the extensive breath of their potential utility in synthetic chemistry, there is a lack of simple, high-yielding methods to deliver them efficiently and as single isomers. In this paper, we present a novel, protecting group free, efficient, and stereoselective approach to the generation of β-halo-enamides. The methodology presented provides a robust synthetic platform from which E- or Z-enamides can be generated in good yields and with complete stereocontrol.
