1359975-13-5Relevant academic research and scientific papers
Discovery of dimeric inhibitors by extension into the entrance channel of HIV-1 reverse transcriptase
Ekkati, Anil R.,Bollini, Mariela,Domaoal, Robert A.,Spasov, Krasimir A.,Anderson, Karen S.,Jorgensen, William L.
, p. 1565 - 1568 (2012)
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase is being pursued with computational guidance. Extension of azine-containing inhibitors into the entrance channel between Lys103 and Glu138 has led to the discovery of potent and structurally novel derivatives including dimeric inhibitors in an NNRTI-linker-NNRTI motif.
