1359976-85-4Relevant academic research and scientific papers
Development of a robust procedure for the copper-catalyzed ring-opening of epoxides with Grignard reagents
Alam, Mahbub,Wise, Christopher,Baxter, Carl A.,Cleator, Ed,Walkinshaw, Andrew
, p. 435 - 441 (2012)
A general procedure for the copper-catalyzed regioselective ring-opening of epoxides with Grignard reagents is described. The procedure developed provides robust reaction conditions which limit the formation of impurities and has been applied successfully using a series of epoxides and Grignard reagents to provide the desired products in >90% yield with excellent regioselectivity and purity.
