1359984-04-5Relevant articles and documents
Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity, β-amyloid aggregation and Ca2+ overload
Wang, Yue,Wang, Fang,Guan, Xin-Lei,Wang, Can-Ming,Cao, Hui,Li, Ming-Xing,Chen, Jian-Guo,Jiang, Feng-Chao,Li, Lei,Yu, Jun-Ping
, p. 6513 - 6522,10 (2012/12/11)
In this study, a series of multipotent phenylthiazole-tacrine hybrids (7a-7e, 8, and 9a-9m) were synthesized and biologically evaluated. Screening results showed that phenylthiazole-tacrine hybrids were potent cholinesterase inhibitors with pIC50/su
Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity, β-amyloid aggregation and Ca2+ overload
Wang, Yue,Wang, Fang,Yu, Jun-Ping,Jiang, Feng-Chao,Guan, Xin-Lei,Wang, Can-Ming,Li, Lei,Cao, Hui,Li, Ming-Xing,Chen, Jian-Guo
, p. 6513 - 6522 (2013/01/14)
In this study, a series of multipotent phenylthiazole-tacrine hybrids (7a-7e, 8, and 9a-9m) were synthesized and biologically evaluated. Screening results showed that phenylthiazole-tacrine hybrids were potent cholinesterase inhibitors with pIC50/su