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136-46-9

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136-46-9 Usage

Brand name

Intracaine Hydrochloride (BristolMyers Squibb).

Check Digit Verification of cas no

The CAS Registry Mumber 136-46-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 6 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 136-46:
(5*1)+(4*3)+(3*6)+(2*4)+(1*6)=49
49 % 10 = 9
So 136-46-9 is a valid CAS Registry Number.
InChI:InChI=1/C15H23NO3.ClH/c1-4-16(5-2)11-12-19-15(17)13-7-9-14(10-8-13)18-6-3;/h7-10H,4-6,11-12H2,1-3H3;1H

136-46-9Downstream Products

136-46-9Relevant articles and documents

Micellisation as the origin of the 'cut off'-effect in homologous series of surface anaesthetics

Eckert,Wachtel

, p. 98 - 100 (2007/10/02)

On the example of the surface anaesthetic homologous series of 4-alkoxybenzoic-diethylaminoethylester-HCl (parethoxycaine) the so-called 'cut off'-effect was studied. The 'cut off'-effect is the phenomenon, that a weaker efficiency or an unefficiency is observed on the higher homologues of therapeutic substances. It is demonstrated that the 'cut off'-effect is referred to the micellisation and aggregation of the higher homologues of the local anaesthetics in aqueous solution. This has the consequence, that the higher homologues cannot diffuse on the pain receptors and so the efficiency is reduced. By the addition of urea the aggregation will be reduced and the chain length-efficiency curve will take a different course.

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