1360066-72-3Relevant academic research and scientific papers
SELECTIVE GRP94 INHIBITORS AND USES THEREOF
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Paragraph 0215; 0220, (2015/02/25)
The disclosure relates to novel selective Grp94 inhibitors, compositions comprising an effective amount of such compounds, and methods to treat or prevent a condition, such as cancer, comprising administering to an animal in need thereof an effective amount of such compounds.
Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94
Patel, Hardik J.,Patel, Pallav D.,Ochiana, Stefan O.,Yan, Pengrong,Sun, Weilin,Patel, Maulik R.,Shah, Smit K.,Tramentozzi, Elisa,Brooks, James,Bolaender, Alexander,Shrestha, Liza,Stephani, Ralph,Finotti, Paola,Leifer, Cynthia,Li, Zihai,Gewirth, Daniel T.,Taldone, Tony,Chiosis, Gabriela
, p. 3922 - 3943 (2015/05/27)
Grp94 is involved in the regulation of a restricted number of proteins and represents a potential target in a host of diseases, including cancer, septic shock, autoimmune diseases, chronic inflammatory conditions, diabetes, coronary thrombosis, and stroke. We have recently identified a novel allosteric pocket located in the Grp94 N-terminal binding site that can be used to design ligands with a 2-log selectivity over the other Hsp90 paralogs. Here we perform extensive SAR investigations in this ligand series and rationalize the affinity and paralog selectivity of choice derivatives by molecular modeling. We then use this to design 18c, a derivative with good potency for Grp94 (IC50 = 0.22 μM) and selectivity over other paralogs (>100- and 33-fold for Hsp90α/β and Trap-1, respectively). The paralog selectivity and target-mediated activity of 18c was confirmed in cells through several functional readouts. Compound 18c was also inert when tested against a large panel of kinases. We show that 18c has biological activity in several cellular models of inflammation and cancer and also present here for the first time the in vivo profile of a Grp94 inhibitor.
An efficient copper-catalyzed microwave-assisted S-arylation towards the synthesis of 8-arylsulfanyl adenines
Sun, Weilin,Patel, Pallav D.,Stephani, Ralph A.,Chiosis, Gabriela
experimental part, p. 3008 - 3012 (2012/01/05)
We report a microwave-assisted synthetic protocol for the C-S cross-coupling reaction of aryl iodides and 8-mercaptoadenine using CuI and n-Bu4NBr with NaOt-Bu in DMF. The method is rapid, simple, and cost efficient, and leads in high yields to
