1360076-19-2Relevant academic research and scientific papers
Exponential diagnostic signal amplification via dendritic chain reaction: The dendritic effect of a self-immolative amplifier component
Karton-Lifshin, Naama,Shabat, Doron
supporting information; experimental part, p. 386 - 393 (2012/03/22)
Signal amplification techniques are commonly used to boost diagnostic signals. We have recently developed a new approach for exponential signal amplification obtained through a distinctive dendritic chain reaction. Here we report evaluation of the effect of the self-immolative dendritic amplifier component on the signal amplification. Four dendrons with various numbers of end-units were evaluated for the ability to produce exponential signal amplification through self-immolative disassembly pathways. The dendron composed of a first-generation platform with three end-units exhibited the best characteristics with rapid disassembly rate and good stability under aqueous conditions. This study demonstrates the efficiency of molecules based on dendritic structures.
