136009-10-4Relevant academic research and scientific papers
Protecting group improvement by isotopic substitution: Synthesis of the quinone system of Fredericamycin A
Clive,Cantin,Khodabocus,Kong,Tao
, p. 7917 - 7930 (2007/10/02)
Use of a trideuteriomethyl group for protection of phenolic oxygen, instead of the classical methyl group, serves to suppress an unwanted intramolecular hydrogen transfer during radical cyclization. The resulting spiro compound can be converted, by select
Protecting Group Improvement by Isotopic Substitution: Application to the Synthesis of the Quinone System of Fredericamycin A
Clive, Derrick L.J.,Khodabocus, Ahmad,Cantin, Michel,Tao, Yong
, p. 1755 - 1757 (2007/10/02)
Use of a trideuteriomethoxy group for phenol protection, instead of the classical methoxy group, serves to suppress an unwanted intramolecular hydrogen transfer during a radical cyclization experiment, and leads to a spiro compound of a type that can be c
Model Studies Related to the Synthesis of Fredericamycin A
Clive, Derrick L. J.,Khodabocus, Ahmad,Vernon, Peter G.,Angoh, A. Gaetan,Bordeleau, Luc,et al.
, p. 1433 - 1444 (2007/10/02)
A spiro diketone 7 containing a pentamethoxynaphthalene unit, and representing four contiguous rings of the antitumour antibiotic fredericamycin A 1, was constructed by radical spirocyclization.
