Cas 1360106-01-9,methyl (S)-3-(3-(4-chlorobenzyl)-4-(ethylthio)-2,6-dioxo-3,6-dihydro-1,3,5-triazin-1(2H)-yl)-2-methylpropanoate

1360106-01-9

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Basic information

Product Name: methyl (S)-3-(3-(4-chlorobenzyl)-4-(ethylthio)-2,6-dioxo-3,6-dihydro-1,3,5-triazin-1(2H)-yl)-2-methylpropanoate
Synonyms: methyl (S)-3-(3-(4-chlorobenzyl)-4-(ethylthio)-2,6-dioxo-3,6-dihydro-1,3,5-triazin-1(2H)-yl)-2-methylpropanoate
CAS NO:1360106-01-9
Molecular Formula:
Molecular Weight: 397.883
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: methyl (S)-3-(3-(4-chlorobenzyl)-4-(ethylthio)-2,6-dioxo-3,6-dihydro-1,3,5-triazin-1(2H)-yl)-2-methylpropanoate(CAS DataBase Reference)
NIST Chemistry Reference: methyl (S)-3-(3-(4-chlorobenzyl)-4-(ethylthio)-2,6-dioxo-3,6-dihydro-1,3,5-triazin-1(2H)-yl)-2-methylpropanoate(1360106-01-9)
EPA Substance Registry System: methyl (S)-3-(3-(4-chlorobenzyl)-4-(ethylthio)-2,6-dioxo-3,6-dihydro-1,3,5-triazin-1(2H)-yl)-2-methylpropanoate(1360106-01-9)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1360106-01-9(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1360106-01-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,0,1,0 and 6 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1360106-01:
(9*1)+(8*3)+(7*6)+(6*0)+(5*1)+(4*0)+(3*6)+(2*0)+(1*1)=99
99 % 10 = 9
So 1360106-01-9 is a valid CAS Registry Number.

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1360106-01-9Relevant academic research and scientific papers

Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists

Fujii, Yasuhiko,Hirai, Keiichiro,Horiguchi, Tohru,Ichihashi, Yusuke,Itoh, Naohiro,Kai, Hiroyuki,Kameyma, Takayuki,Kasai, Erika,Kurose, Noriyuki,Minami, Kazuhisa,Murakami, Yuki,Nakamura, Kenichiroh,Ogawa, Hiroko,Onodera, Naohiro,Sekimoto, Ryouko,Shinohara, Shunji,Shintani, Takuya,Yoneda, Sosuke,Yoshida, Osamu

supporting information, (2021/10/04)

In previous work, we discovered a lead compound and conducted initial SAR studies on a novel series of dioxotriazines to identify the compound as one of the P2X3 receptor antagonists. This compound showed high P2X3 receptor selectivity and a strong analgesic effect. Although not selected for clinical development, the compound was evaluated from various aspects as a tool compound. In the course of the following study, the molecular structures of the dioxotriazines were modified based on pharmacokinetic/pharmacodynamic (PK/PD) analyses. As a result of these SAR studies, Sivopixant (S-600918) was identified as a clinical candidate with potent and selective antagonistic activity (P2X3 IC50, 4.2 nM; P2X2/3 IC50, 1100 nM) and a strong analgesic effect in the rat partial sciatic nerve ligation model (Seltzer model) of allodynia (ED50, 0.4 mg/kg).

AMINO-TRIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING SAID DERIVATIVES

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Paragraph 0595-0597, (2016/10/07)

The present invention provides novel compounds having a P2X 3 and/or P2X 2/3 receptor antagonistic activity. A compound of Formula (I): wherein R a and R b , and R d and R e are taken together to form oxo or the like; R 4a and R 4b are hydrogen or the lik

AMINOTRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

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, (2016/05/19)

The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic activity. A compound of Formula (I): wherein Ra and Rb, and Rd and Re are taken together to

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