1360145-99-8

Basic information

• Product Name: (1S,2S)-(+)-2-phthalimido-1-acetoxy-cyclohexane
• Synonyms: (1S,2S)-(+)-2-phthalimido-1-acetoxy-cyclohexane
• CAS NO: 1360145-99-8
• Molecular Weight: 287.315
• Mol File: 1360145-99-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,2S)-(+)-2-phthalimido-1-acetoxy-cyclohexane(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-(+)-2-phthalimido-1-acetoxy-cyclohexane(1360145-99-8)
• EPA Substance Registry System: (1S,2S)-(+)-2-phthalimido-1-acetoxy-cyclohexane(1360145-99-8)

Safety Data

• Hazardous Substances Data: 1360145-99-8(Hazardous Substances Data)

Upstream product

• 931-16-8 (+/-)-trans-2-aminocyclohexanol 
• 5399-20-2 2-(2-hydroxy-cyclohexyl)-isoindole-1,3-dione 
• 85-44-9 phthalic anhydride 

Downstream Products

• 931-15-7 (1S,2S)-trans-2-aminocyclohexanol 

Relevant articles and documents

Cyclic trans-β-amino alcohols: Preparation and enzymatic kinetic resolution

Enantioenriched cyclic β-amino alcohols, trans-2-aminocyclohexanols (ee, >99%), trans-2-aminocyclopentanols (ee, >99%), trans-1-amino-2- indanols (ee, >99%) and trans-2-amino-1-indanols (ee, ～98%) were prepared in high yields via an Arthrobacter sp. Lipase/PLAP catalyzed kinetic resolution of racemic phthalimido acetates. The addition of toluene as a co-solvent dramatically improved the hydrolysis and enantioselectivity, whereas for indanols, substrate immobilization on Celite improved the efficacy of the kinetic resolution.