1360179-76-5

Basic information

• Product Name: N-benzyl-6-morpholino-N-nitrosopyrimidin-4-amine
• Synonyms: N-benzyl-6-morpholino-N-nitrosopyrimidin-4-amine
• CAS NO: 1360179-76-5
• Molecular Weight: 299.332
• Mol File: 1360179-76-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-benzyl-6-morpholino-N-nitrosopyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-6-morpholino-N-nitrosopyrimidin-4-amine(1360179-76-5)
• EPA Substance Registry System: N-benzyl-6-morpholino-N-nitrosopyrimidin-4-amine(1360179-76-5)

Safety Data

• Hazardous Substances Data: 1360179-76-5(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 1360179-68-5 N-benzyl-6-chloro-N-nitrosopyrimidin-4-amine 
• 61667-16-1 benzyl-(6-chloropyrimidin-4-yl)-amine 
• 100-46-9 benzylamine 

Downstream Products

• 1360179-77-6 N-benzyl-(6-morpholino-4-pyrimidinyl)-acetamide 

Relevant articles and documents

The first example of the Fischer-Hepp type rearrangement in pyrimidines

A N-nitroso moiety can be used for the activation of chloropyrimidines toward a nucleophilic substitution reaction with amines. The subsequent treatment of the obtained products with aq H2SO4 can lead to either N-denitrosation to obtain 4,6-pyrimidinediamines or to a Fischer-Hepp type rearrangement to obtain 5-nitroso-4,6-pyrimidinediamines. It was found that the outcome of the reaction strongly depends on the structure of the pyrimidines. Activation of the pyrimidine ring by three groups with a positive mesomeric effect is crucial for the intramolecular nitroso group migration.