1360180-13-7Relevant academic research and scientific papers
Pd(II)/Bronsted acid catalyzed enantioselective allylic C-H activation for the synthesis of spirocyclic rings
Chai, Zhuo,Rainey, Trevor J.
, p. 3615 - 3618 (2012/04/23)
A Pd(II)/Bronsted acid catalyzed migratory ring expansion for the synthesis of indene derivatives possessing a stereogenic spirocyclic carbon center was developed. This transformation is believed to mechanistically proceed via enantioselective allylic C-H activation with concomitant semipinacol ring expansion to the nascent π-allylpalladium species. Enantioselectivities as high as 98% ee were attainable.
