1360187-05-8Relevant academic research and scientific papers
Synthesis, characterization and catalytic behaviour of a palladium complex bearing a hydroxy-functionalized N-heterocyclic carbene ligand
Mariconda, Annaluisa,Grisi, Fabia,Costabile, Chiara,Falcone, Salvatore,Bertolasi, Valerio,Longo, Pasquale
, p. 762 - 769 (2014)
The synthesis of a new stable palladium(II) complex (3) featuring an unsymmetrical substituted N-heterocyclic carbene (NHC) ligand with a pendant hydroxy-functionalized group was successfully accomplished via transmetalation of the corresponding bis-NHC silver(I) complex (2). Solid-state structures of both 2 and 3 were determined by single-crystal X-ray diffraction. The catalytic behaviour of 3 in the direct regioselective arylation of furan and thiophene derivatives by using challenging aryl halides was studied, revealing that 3 was capable of promoting these environmentally attractive coupling reactions to afford arylated heterocycles in moderate to good yields.
Generation of metalated thiophenes with Grignard reagent and catalytic secondary amine for the cross coupling reaction with aryl halides
Tanaka, Shota,Tanaka, Daiki,Sugie, Atsushi,Mori, Atsunori
experimental part, p. 1173 - 1176 (2012/03/26)
The reaction of thiophene derivatives with Grignard reagent (EtMgCl) and a catalytic amount of amine (Cy2NH) induced the metalation at the α-position. Following addition of several aryl halides in the presence of a nickel or palladium catalyst afforded C-H arylated products in good to excellent yields. The method was successfully applied to facile synthesis of differently-substituted 2,5-diarylthiophenes.
