1360187-06-9Relevant academic research and scientific papers
Generation of metalated thiophenes with Grignard reagent and catalytic secondary amine for the cross coupling reaction with aryl halides
Tanaka, Shota,Tanaka, Daiki,Sugie, Atsushi,Mori, Atsunori
, p. 1173 - 1176 (2012)
The reaction of thiophene derivatives with Grignard reagent (EtMgCl) and a catalytic amount of amine (Cy2NH) induced the metalation at the α-position. Following addition of several aryl halides in the presence of a nickel or palladium catalyst afforded C-H arylated products in good to excellent yields. The method was successfully applied to facile synthesis of differently-substituted 2,5-diarylthiophenes.
