1360187-08-1Relevant academic research and scientific papers
Generation of metalated thiophenes with Grignard reagent and catalytic secondary amine for the cross coupling reaction with aryl halides
Tanaka, Shota,Tanaka, Daiki,Sugie, Atsushi,Mori, Atsunori
experimental part, p. 1173 - 1176 (2012/03/26)
The reaction of thiophene derivatives with Grignard reagent (EtMgCl) and a catalytic amount of amine (Cy2NH) induced the metalation at the α-position. Following addition of several aryl halides in the presence of a nickel or palladium catalyst afforded C-H arylated products in good to excellent yields. The method was successfully applied to facile synthesis of differently-substituted 2,5-diarylthiophenes.
