13602-59-0

Basic information

• Product Name: Pyridine,2,4-dichloro-, 1-oxide
• Synonyms: 2,4-DichloropyridineN-oxide
• CAS NO: 13602-59-0
• Molecular Formula: C₅H₃Cl₂NO
• Molecular Weight: 163.9894
• Mol File: 13602-59-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 344.2 °C at 760 mmHg
• Flash Point: 162 °C
• Density: 1.47 g/cm³
• CAS DataBase Reference: Pyridine,2,4-dichloro-, 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine,2,4-dichloro-, 1-oxide(13602-59-0)
• EPA Substance Registry System: Pyridine,2,4-dichloro-, 1-oxide(13602-59-0)

Safety Data

• Hazardous Substances Data: 13602-59-0(Hazardous Substances Data)

Upstream product

• 14432-16-7 2-chloro-4-nitropyridine-N-oxide 
• 26452-80-2 2,4-dichloropyridine 

Downstream Products

• 1584220-13-2 N-(4-((2-amino-6-((3-((methylsulfonyl)methyl)phenyl)amino)pyridin-4-yl)oxy)-3-fluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1584220-12-1 N-(4-((2-carbamoyl-6-((3-((methylsulfonyl)methyl)phenyl)amino)pyridin-4-yl)oxy)-3-fluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1584220-11-0 N-(4-((2-cyano-6-((3-((methylsulfonyl)methyl)phenyl)amino)pyridin-4-yl)oxy)-3-fluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1584220-31-4 4-(4-amino-2-fluorophenoxy)-6-chloropicolinonitrile 
• 1584220-30-3 N-(4-((2-chloro-6-cyanopyridin-4-yl)oxy)-3-fluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 40314-71-4 4,6-dichloropyridine-2-carbonitrile 
• 881891-52-7 cis-N-benzyl-N'-(4-chloro-1-oxidopyridin-2-yl)cyclohexane-1,4-diamine 

Relevant articles and documents

A novel reagent combination for the oxidation of highly electron deficient pyridines to N-oxides: trifluoromethanesulfonic anhydride/sodium percarbonate

A novel reagent combination, Tf2O/Na2CO3·1.5H2O2, has been developed for the oxidation of highly electron deficient pyridines to their corresponding N-oxides. The N-oxidation reaction, utilizing the in situ generated peracid, proceeds under mild conditions that allow for a number of functional groups and substitution patterns on the pyridine ring.

Nature of the Nucleophilic Oxygenation Reagent Is Key to Acid-Free Gold-Catalyzed Conversion of Terminal and Internal Alkynes to 1,2-Dicarbonyls

2,3-Dichloropyridine N-oxide, a novel oxygen transfer reagent, allows the conductance of the gold(I)-catalyzed oxidation of alkynes to 1,2-dicarbonyls in the absence of any acid additives and under mild conditions to furnish the target species, including those derivatized by highly acid-sensitive groups. The developed strategy is effective for a wide range of alkyne substrates such as terminal- and internal alkynes, ynamides, alkynyl ethers/thioethers, and even unsubstituted acetylene (40 examples; yields up to 99%). The oxidation was successfully integrated into the trapping of reactive dicarbonyls by one-pot heterocyclization and into the synthesis of six-membered azaheterocycles. This synthetic acid-free route was also successfully applied for the total synthesis of a natural 1,2-diketone.

Highly efficient and selective phosphorylation of amino acid derivatives and polyols catalysed by 2-aryl-4-(dimethylamino)pyridine-N-oxides-towards kinase-like reactivity

The chemoselective phosphorylation of hydroxyl containing amino acid derivatives and polyols by phosphoryl chlorides catalyzed by 2-aryl-4-(dimethylamino)pyridine-N-oxides is described.