136036-73-2Relevant academic research and scientific papers
Process for the preparation of an antiviral agent
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, (2008/06/13)
Racemic Feist's acid is treated with (R)-(+) -α-methylbenzylamine to yield (1R-trans)-3-methylene -cyclopropane-1,2-dicarboxylic acid, (R)-α-methylbenzyl-amine (1:1) salt. This salt can then be converted to (1R-trans)-3-methylene-1,2-cyclopropanedicarboxy
Process for the preparation of an antiviral agent
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, (2008/06/13)
Racemic Feist's acid is treated with (R)-(+)-α-methylbenzylamine to yield (1R-trans)-3-methylenecyclopropane-1,2-dicarboxylic acid, (R)-α-methylbenzylamine (1:1) salt. This salt can then be converted to (1R-trans)-3-methylene-1,2-cyclopropanedicarboxylic acid, dimethyl ester which is an intermediate in the preparation of the antiviral agent [1R-(1α,2β, 3α)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-1,9-dihydro-6H-purin-6-one. The improved process also enables the recovery of racemic Feist's acid from the resolution.
Bis (hydroxymethyl) cyclobutyl triazolopyrimidines
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, (2008/06/13)
Antiviral activity is exhibited by compounds having the formula STR1 and its pharmaceutically acceptable salts wherein R1 is STR2 R6 is hydrogen, alkyl, substituted alkyl, or aryl; and R7 and R8 are independentl
Process for preparing an optically active cyclobutane nucleoside
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, (2008/06/13)
A process for the preparation of the optically active compound [IR-(1α, 2β, 3α)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-6H-purin-6-one, represented by the formula: STR1 and novel intermediates are described.
