1360435-79-5Relevant academic research and scientific papers
Concise one-pot preparation of unique bis-pyrrolidinone tetrazoles
Gunawan, Steven,Petit, Joachim,Hulme, Christopher
, p. 160 - 163 (2012)
A one-pot, two-step synthesis of bis-pyrrolidinone tetrazoles has been established via the Ugi-Azide reaction using methyl levulinate, primary amines, isocyanides and azidotrimethylsilane with subsequent acid treatment to catalyze the lactam formation. The efficiency of the protocol was established followed by a successful transition to library production in four 24-well plates.
