1360445-46-0Relevant academic research and scientific papers
Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury
Krenitsky, Véronique Plantevin,Delgado, Mercedes,Nadolny, Lisa,Sahasrabudhe, Kiran,Ayala, Leticia,Clareen, Steven S.,Hilgraf, Robert,Albers, Ronald,Kois, Adam,Hughes, Kevin,Wright, Jonathan,Nowakowski, Jacek,Sudbeck, Elise,Ghosh, Sutapa,Bahmanyar, Sogole,Chamberlain, Philip,Muir, Jeff,Cathers, Brian E.,Giegel, David,Xu, Li,Celeridad, Maria,Moghaddam, Mehran,Khatsenko, Oleg,Omholt, Paul,Katz, Jason,Pai, Sema,Fan, Rachel,Tang, Yang,Shirley, Michael A.,Benish, Brent,Blease, Kate,Raymon, Heather,Bhagwat, Shripad,Henderson, Ian,Cole, Andrew G.,Bennett, Brydon,Satoh, Yoshitaka
scheme or table, p. 1427 - 1432 (2012/04/04)
In this Letter we describe the optimization of an aminopurine lead (1) with modest potency and poor overall kinase selectivity which led to the identification of a series of potent, selective JNK inhibitors. Improvement in kinase selectivity was enabled by introduction of an aliphatic side chain at the C-2 position. CC-359 (2) was selected as a potential clinical candidate for diseases manifested by ischemia reperfusion injury.
