1360447-34-2Relevant academic research and scientific papers
Asymmetric synthesis of highly functionalized γ-lactams through an organocatalytic aza-Michael-Michael reaction cascade using fumaric acid amide esters as multi-reactive substrates
Yokosaka, Takuya,Hamajima, Akinari,Nemoto, Tetsuhiro,Hamada, Yasumasa
, p. 1245 - 1248 (2012/03/26)
We developed a novel method for the asymmetric synthesis of highly functionalized γ-lactams through an organocatalytic aza-Michael-Michael reaction cascade using fumaric acid amide esters as multi-reactive substrates. Using chiral primary or secondary amine organocatalysts, we obtained two types of γ-lactams with three contiguous chiral centers in moderate to good yield with excellent enantioselectivity and diastereoselectivity.
