1360451-33-7

Upstream product

• 112399-50-5 2-bromo-5-fluorobenzyl bromide 
• 127792-49-8 2-(2-bromo-5-fluorophenyl)acetonitrile 
• 1383381-25-6 2-(5-fluoro-2-((triethylsilyl)ethynyl)phenyl)acetonitrile 

Downstream Products

• 1360451-35-9 2-(2-((2-chloropyrimidin-4-yl)ethynyl)-5-fluorophenyl)acetonitrile 
• 1360449-47-3 (5-fluoro-2-{2-[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)pyrimidin-4-yl]ethyl}phenyl)acetonitrile 
• 1360451-36-0 2-(2-(2-(2-chloropyrimidin-4-yl)ethyl)-5-fluorophenyl)acetonitrile 

Relevant academic research and scientific papers

Gold-catalyzed 1,2-oxoarylations of nitriles with pyridine-derived oxides

We report the first success in the gold-catalyzed oxoarylations of nitriles with pyridine-derived N-oxides using gold carbenes as initiators. These oxoarylations were also achieved satisfactorily in intermolecular three-component oxidations, including diverse alkenyldiazo esters, nitriles, and pyridine-based oxides. Spill the (car)benes: Reported herein is the first successful gold-catalyzed oxoarylation of nitriles with pyridine-derived N-oxides using gold carbenes as initiators (see scheme; DCE=1,2-dichloroethane, IPr=1,3-bis(diisopropylphenyl)imidazol-2-ylidene). These oxoarylations were also achieved satisfactorily in intermolecular three-component oxidations using a variety of alkenyldiazo esters, nitriles, and pyridine-based N-oxides.

PYRIMIDINE DERIVATIVES AS FAK INHIBITORS

Compounds of the formula (I), in which R1, R2 and R3 have the meanings indicated in Claim 1, are kinase inhibitors and can be employed, inter alia, for the treatment of tumours.