1360458-85-0Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of new N 4-Substituted 2′-deoxy-2′-fluoro-4′-azido cytidine derivatives as potent anti-HBV agents
Lv, Zhigang,He, Wu,Tian, Xianhai,Kang, Jinfeng,Liu, Yangxue,Peng, Youmei,Zheng, Liyun,Wang, Qingduan,Yu, Wenquan,Chang, Junbiao
, p. 103 - 110 (2015)
A series of new 2′-deoxy-2′-β-fluoro-4′-azido-β-d-arabinofuranosyl cytidine derivatives bearing heteroatom-containing N4-substituents were designed and synthesized. Antiviral screening in HepG2.2.15 cells identified three analogs (1a, 1d and 1g
NUCLEOSIDE DERIVATIVES, SYNTHESIS METHODS AND USES THEREOF FOR PREPARING ANTI-TUMOR AND ANTI-VIRUS MEDICAMENTS
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Paragraph 0028-0029, (2013/07/25)
The present invention relates to the field of pharmacochemistry. Disclosed are fluorinated and azido-substituted pyrimidine nucleoside derivatives, and preparation methods and uses thereof. The structural formula is as shown (I). These compounds can be used for preparing medicaments for treating diseases such as tumors and viral infections, and can be used separately or in combination with other medicaments. The compounds also have effective activity against diseases such as tumors and viral infections, while having few side effects, and thus have potential application value.
