1360468-01-4Relevant academic research and scientific papers
One-pot synthesis of useful heterocycles in medicinal chemistry using a cascade strategy
Wu, Guiyong,Yin, Weiyu,Shen, Hong C.,Huang, Yong
supporting information; experimental part, p. 580 - 585 (2012/04/23)
To access useful heterocycles in medicinal chemistry such as pyridazinones, dihydropyrimidinones, and dihydropyrimidinthiones, a "green" mild and highly efficient one-pot triple cascade was developed involving a Claisen-decarboxylation, electrophilic reaction, and subsequent heterocyclization. In addition, indazoles and benzofurans could also be constructed via a double cascade. To develop the cascade process, a direct Claisen-decarboxylation reaction was firstly optimized. This reaction can then couple with electrophilic reactions including alkylation, Michael addition or aldol reaction to enable the preparation of various aryl ketones in a one-pot fashion. The Royal Society of Chemistry 2012.
