136051-41-7 Usage
General Description
Justiciresinol is a lignan compound found in the fruits and seeds of various plants, including Justicia and Linum species. It is known for its antioxidant and anti-inflammatory properties, making it a potential candidate for the treatment of various diseases and conditions. Justiciresinol has been studied for its potential role in preventing chronic diseases such as cancer, heart disease, and diabetes, as well as its ability to modulate immune responses and reduce inflammation. Additionally, it has shown promise as a natural alternative to hormone replacement therapy, with potential benefits for menopausal symptoms and bone health. Overall, justiciresinol is a natural compound with diverse potential health benefits and warrants further research to fully understand its therapeutic potential.
Check Digit Verification of cas no
The CAS Registry Mumber 136051-41-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,0,5 and 1 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 136051-41:
(8*1)+(7*3)+(6*6)+(5*0)+(4*5)+(3*1)+(2*4)+(1*1)=97
97 % 10 = 7
So 136051-41-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H26O7/c1-25-17-9-13(4-5-16(17)23)21-15(10-22)14(11-28-21)6-12-7-18(26-2)20(24)19(8-12)27-3/h4-5,7-9,14-15,21-24H,6,10-11H2,1-3H3/t14-,15-,21+/m0/s1
136051-41-7Relevant articles and documents
Pinoresinol-lariciresinol reductase: Substrate versatility, enantiospecificity, and kinetic properties
Davin, Laurence B.,Hwang, Julianne K.,Lewis, Norman G.,Moinuddin, Syed G. A.
, (2020/03/26)
Two western red cedar pinoresinol-lariciresinol reductase (PLR) homologues were studied to determine their enantioselective, substrate versatility, and kinetic properties. PLRs are downstream of dirigent protein engendered, coniferyl alcohol derived, stereoselective coupling to afford entry into the 8- and 8′-linked furofuran lignan, pinoresinol. Our investigations showed that each PLR homolog can enantiospecifically metabolize different furofuran lignans with modified aromatic ring substituents, but where phenolic groups at both C4/C4′ are essential for catalysis. These results are consistent with quinone methide intermediate formation in the PLR active site. Site-directed mutagenesis and kinetic measurements provided additional insight into factors affecting enantioselectivity and kinetic properties. From these data, PLRs can be envisaged to allow for the biotechnological potential of generation of various lignan skeleta, that could be differentially “decorated” on their aromatic ring substituents, via the action of upstream dirigent proteins.
