1360544-83-7Relevant academic research and scientific papers
Synthesis of water-soluble scaffolds for peptide cyclization, labeling, and ligation
Smeenk, Linde E. J.,Dailly, Nicolas,Hiemstra, Henk,Van Maarseveen, Jan H.,Timmerman, Peter
, p. 1194 - 1197 (2012/05/04)
The synthesis and applications of water-soluble scaffolds that conformationally constrain side chain unprotected linear peptides containing two cysteines are described. These scaffolds contain a functionality with orthogonal reactivity to be used for labeling and ligation. This is illustrated by the chemical ligation of two dissimilar constrained peptides via oxime ligation or strain-promoted azide-alkyne cycloaddition in aqueous media.
Application of strain-promoted azide-alkyne cycloaddition and tetrazine ligation to targeted fc-drug conjugates
Thomas, Joshua D.,Cui, Huiting,North, Patrick J.,Hofer, Thomas,Rader, Christoph,Burke, Terrence R.
, p. 2007 - 2013 (2013/01/15)
We have previously described an approach whereby antibody Fc fragments harboring a single C-terminal selenocysteine residue (Fc-Sec) are directed against a variety of targets by changing the peptide or small molecule to which they are conjugated. In the p
