1360544-96-2Relevant academic research and scientific papers
Synthesis of water-soluble scaffolds for peptide cyclization, labeling, and ligation
Smeenk, Linde E. J.,Dailly, Nicolas,Hiemstra, Henk,Van Maarseveen, Jan H.,Timmerman, Peter
, p. 1194 - 1197 (2012)
The synthesis and applications of water-soluble scaffolds that conformationally constrain side chain unprotected linear peptides containing two cysteines are described. These scaffolds contain a functionality with orthogonal reactivity to be used for labeling and ligation. This is illustrated by the chemical ligation of two dissimilar constrained peptides via oxime ligation or strain-promoted azide-alkyne cycloaddition in aqueous media.
