1360548-52-2Relevant academic research and scientific papers
A concise total synthesis of (±)-trigonoliimine B
Buyck, Thomas,Wang, Qian,Zhu, Jieping
, p. 1338 - 1341 (2012/05/20)
Trigonoliimine B, a hexacyclic alkaloid, is synthesized in seven steps from simple starting materials. The synthesis features the use of an α-isocyanoacetate as a glycine template for the preparation of an α,α-disubstituted α-amino ester that is appropriately functionalized for the construction of C, D, and E rings. Sulfolane was found to be the solvent of choice for the unprecedented Bischler-Napieralski reaction implemented for the construction of a seven-membered ring with concurrent formation of an exo-imine function.
