1360567-66-3Relevant academic research and scientific papers
A novel ditopic ring-expanded N-heterocyclic carbene ligand-assisted Suzuki-Miyaura coupling reaction in aqueous media
Karaca, Emine ?zge,Akko?, Mitat,Nawaz Tahir, Muhammad,Ar?c?, Cengiz,?mik, Fatma,Gürbüz, Nevin,Ya?ar, Sedat,?zdemir, ?smail
, p. 3529 - 3532 (2017)
A series of seven-membered ditopic ring-expanded N-heterocyclic carbene (dre-NHC) precursors, bearing sterically demanding and electron-rich aryl groups, were synthesised in moderate yields via the reaction of 1,2,4,5-tetrakis(bromomethyl)benzene with the corresponding N,N′-diarylformamidines in the presence of K2CO3 in acetonitrile under an air atmosphere. All new compounds were characterised by HRMS, NMR spectroscopy, and microanalysis, as well as X-ray crystallography for compound 1c. The development of an efficient catalytic system for the Suzuki-Miyaura coupling reaction of aryl chlorides with various boronic acids was also investigated using the in situ generated dre-NHC ligands.
