136057-66-4

Upstream product

• 115246-57-6 (4S,5S)-5-allyl-4-methoxy-2-oxazolidinone 
• 104882-44-2 (2S,3S)-2-(tert-butoxycarboxamido)-1-cyclohexyl-5-hexen-3-ol 
• 35166-78-0 cyclohexylmethyl magnesium bromide 
• 136057-63-1 trans-5-allyl-4-phenylthio-2-oxazolidinone 

Downstream Products

• 136057-67-5 (4S,5S)-5-Allyl-4-cyclohexylmethyl-2-oxo-oxazolidine-3-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

DIOXACYCLOALKANE COMPOUND HAVING RENIN-INHIBITORY ACTIVITY

Dioxacycloalkane compounds of the formula [1] STR1 wherein A is STR2 wherein W is STR3 X is--CO--or--SO 2--; Y is--CH. sub.2--,--O--or--NR 25--; and R 1 is an aralkyl which may be substituted by lower alkoxy;R 2 is a hydrogen atom or a lower alkyl;R 3 is--(CH 2)d-SR 26 or STR4 R. sup.4 and R 5 are each a hydrogen atom or a lower alkyl; and E is--C(R. sup.29)(R 30)--or--CH 2 CH 2--, pharmaceutically acceptable salts thereof, intermediates for producing said compounds, and methods for producing said intermediates. The compounds of the formula [1] have a strong inhibitory activity against renin and show continuous hypotensive action by oral administration. They are useful as hypotensive agents or therapeutic agents for heart failure.

Renin inhibitors containing new P1-P1' dipeptide mimetics with heterocycles in P1'

A series of renin inhibitors containing new P1-P1' dipeptide mimetics are presented. The P1-P1' mimetics were obtained from (4S,5S)-3-(tert- butoxycarbonyl)-4-(cyclohexylmethyl)-5-[(ω-mesyloxy)alkyl]-2,2- dimeth

LEWIS ACID-PROMOTED DIRECT SUBSTITUTION OF 4-METHOXY- AND 4-PHENYLTHIO-2-OXAZOLIDINONES BY ALKYL CUPRATES. FACILE PREPARATION OF (3S,4S)-STATINE AND (3S,4S)-CYCLOHEXYLSTATINE.

Treatment of 4-methoxy- and 4-phenylthio-2-oxazolidinones with a combination of cuprates and BF3 results in smooth formation of 4-alkyl- and 4-aryl derivatives in high yield.By this method, the titled compounds of biological interest are readily synthesiz