1360619-98-2

Upstream product

• 533-67-5 2-Deoxy-D-ribose 
• 50907-65-8 2-deoxy-D-erythro-pentose cyclic 1,3-propanediyl mercaptal 
• 452-51-7 D-2-deoxyribose 
• 1360619-97-1 (E)-3-(((2R,4S,5R)-4-((1,3-dithian-2-yl)methyl)-2-phenyl-1,3-dioxan-5-yl)oxy)-1-(2,5-dimethyl-1H-pyrrol-1-yl)prop-2-en-1-one 
• 1360619-96-0 1-(2,5-dimethyl-1H-pyrrol-1-yl)prop-2-yn-1-one 
• 1021700-90-2 (2R,4S,5R)-2-phenyl-4-[(1,3-dithian-2-yl)methyl]-1,3-dioxan-5-ol 

Downstream Products

• 1360619-99-3 (2R,4aR,6S,8aS)-2-phenyl-6-[2-(2,5-dimethyl-1H-pyrrol-1-yl)-2-oxoethyl]tetrahydro-1,3-dioxino[4,5-e]pyran-7-one 

Relevant academic research and scientific papers

Samarium-mediated intramolecular cross-couplings of an α,β-unsaturated N-acylpyrrole

The first example of an α,β-unsaturated N-acylpyrrole undergoing a SmI2-mediated cyclization is reported. In contrast to other unsaturated units, the intermediate samarium enolate readily engages in aldol-type reactions, necessitating careful control of the reaction conditions.

Stetter reactions of unsaturated 1-acyl-1H-pyrroles

α,β-Unsaturated 1-acyl-1H-pyrroles are employed as enabling units for the construction of 1,4-dicarbonyl systems using the organocatalytic Stetter reaction. The enhanced electrophilicity of the 1-acyl-1H-pyrrole unit allows for the catalytic construction of fused and non-fused pyranones from aliphatic aldehydes, is compatible with aromatic aldehydes, and also facilitates an intermolecular variant of the reaction involving both aromatic and aliphatic aldehydes.