1360788-73-3Relevant academic research and scientific papers
Synthesis of symmetric 1,4-diamino-2-butynes via a Cu(I)-catalyzed one-pot A3-coupling/decarboxylative coupling of a propiolic acid, an aldehyde, and an amine
Feng, Huangdi,Ermolat'ev, Denis S.,Song, Gonghua,Van Der Eycken, Erik V.
experimental part, p. 5149 - 5154 (2012/07/14)
A novel microwave-assisted approach for the one-pot Cu(I)-catalyzed A 3-coupling/decarboxylative coupling (PA2-coupling) of a propiolic acid, an aldehyde, and an amine, resulting in the formation of diversely substituted 1,4-diamino-2-butynes,is described. It is noteworthy that this new multicomponent coupling provides an efficient access to introduce alkyl and aryl group at the 1,4-position of the 1,4-diamino-2-butynes.
Copper(I)-catalyzed deacetylenative coupling of propargylic amines: An efficient synthesis of symmetric 1,4-diamino-2-butynes
Kim, Yongeun,Nakamura, Hiroyuki
supporting information; experimental part, p. 12561 - 12563 (2011/12/03)
Deacetylenative coupling: Propargylic amines undergo copper-catalyzed deacetylenative coupling to give the symmetric 1,4-diamino-2-butynes. In the presence of a base, the Glaser-type homocoupling takes place, whereas in the absence of a base the deacetylenative coupling takes place (see scheme).
