1360880-35-8Relevant academic research and scientific papers
Design of barbiturate-nitrate hybrids that inhibit MMP-9 activity and secretion
Wang, Jun,O'Sullivan, Shane,Harmon, Shona,Keaveny, Ray,Radomski, Marek W.,Medina, Carlos,Gilmer, John F.
, p. 2154 - 2162 (2012)
We describe a new type of barbiturate-based matrix metalloproteinase (MMP) inhibitor incorporating a nitric oxide (NO) donor/mimetic group (series 1). The compounds were designed to inhibit MMP at enzyme level and to attenuate MMP-9 secretion arising from
