1360889-66-2Relevant academic research and scientific papers
Cobalt-Catalyzed Enantioselective Hydroarylation of 1,6-Enynes
Whyte, Andrew,Torelli, Alexa,Mirabi, Bijan,Prieto, Liher,Rodríguez, José F.,Lautens, Mark
, p. 9510 - 9517 (2020)
An asymmetric hydroarylative cyclization of enynes involving a C-H bond cleavage is reported. The cobalt-catalyzed cascade generates three new bonds in an atom-economical fashion. The products were obtained in excellent yields and excellent enantioselectivities as single diastereo- and regioisomers. Preliminary mechanistic studies indicate that the reaction shows no intermolecular C-H crossover. This work highlights the potential of cobalt catalysis in C-H bond functionalization and enantioselective domino reactivity.
Rhodium-catalyzed asymmetric [2+2+2] cyclization of 1,6-enynes and aldehydes
Ishida, Mana,Shibata, Yu,Noguchi, Keiichi,Tanaka, Ken
supporting information; experimental part, p. 12578 - 12581 (2011/12/04)
Asymmetric catalysis: The rhodium-catalyzed asymmetric [2+2+2] cyclization of 1,6-enynes and aldehydes was achieved by using a cationic rhodium(I)/(R)-binap complex as a catalyst (see scheme; cod=1,5-cyclooctadiene). Coordination of the substrate heteroatom to the cationic rhodium plays an important role in this cyclization reaction.
