1360895-16-4Relevant academic research and scientific papers
Carboxylate-directed tandem functionalisations of α,β- dihaloalkenoic acids with 1-alkynes: A straightforward access to (Z)-configured, α,β-substituted γ-alkylidenebutenolides
Inack Ngi, Samuel,Cherry, Khalil,Héran, Virginie,Commeiras, Laurent,Parrain, Jean-Luc,Duchêne, Alain,Abarbri, Mohamed,Thibonnet, Jér?me
, p. 13692 - 13696 (2011)
An easy and mild copper(I)-catalysed lactonisation of readily available (E)-2,3-dihalopropenoic acid derivatives regio- and stereoselectively leads to rarely described (Z)-3-halo-5-ylidene-5H-furan-2-ones. These compounds are subsequently able to undergo classical Pd-catalysed cross-coupling reactions, providing 3-substituted and 3,4-disubstituted 5-ylidene-5H-furan-2-ones (see scheme).
