1360925-83-2

Upstream product

• 20445-31-2 R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid 
• 1360926-26-6 2(R)-hydroxy-3(R)-methyl-3-propyl-4-oxobutyric acid ethyl ester 
• 123-15-9 2-methylvaleraldehyde 

Relevant academic research and scientific papers

Histidine-catalyzed asymmetric aldol addition of enolizable aldehydes: Insights into its mechanism

Extensive studies of asymmetric cross-aldol addition between enolizable aldehydes are described and provide a deeper insight into histidine-catalyzed aldol additions. In particular, aspects of enantio- as well as diastereoselectivity of these reactions are discussed. Rules and predictions of configurative outcome are explained by using different transition-state models. These discussions are confirmed by extensive computations.